Rebound acid hypersecretion

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Rebound nocturnal hypersecretion after four weeks treatment with an H2 receptor antagonist.

Daytime intragastric pH, fasting and meal stimulated serum gastrin and nocturnal acid output were studied in eight male duodenal ulcer patients before, during and two days after completing nizatidine 300 mg nocte (20:00 h) for four weeks. Median nocturnal acid output (mmol/10 h) decreased during treatment to 11.6 (range 0.4-26.7) compared with pretreatment value of 39.4 (9.8-91.2); median acid ...

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ژورنال

عنوان ژورنال: Alimentary Pharmacology & Therapeutics

سال: 2007

ISSN: 0269-2813,1365-2036

DOI: 10.1111/j.1365-2036.2007.03263.x